Rapamycin

Rapamycin (Sirolimus) is an mTOR inhibitor traditionally used as an immunosuppressant in transplant medicine. In recent years, it has gained growing interest in the field of longevity and anti-aging medicine due to its ability to modulate cellular aging, inflammation, and metabolic health. When dosed intermittently and at low levels, Rapamycin may help extend lifespan, delay age-related disease onset, and support health span without the immune suppression associated with high-dose use.

Benefits:

• May extend lifespan and delay age-related disease
• Supports cellular autophagy and DNA repair
• Reduces chronic inflammation (“inflammaging”)
• Improves metabolic health and insulin sensitivity
• Works synergistically with fasting, exercise, and AMPK activators (e.g., Metformin)
  
  
  
  

Rapamycin works by selectively inhibiting the mammalian target of rapamycin complex 1 (mTORC1), a key regulator of aging and growth:

1. mTORC1 Inhibition
   • mTORC1 controls cell growth, proliferation, and protein synthesis. Rapamycin slows this pathway, promoting cellular repair, autophagy, and metabolic efficiency—hallmarks of anti-aging.

Intermittent, Low-Dose Strategy
• When used once or twice weekly at low doses, it avoids immunosuppression while preserving its anti-aging and regenerative benefits.